Table 2.
Meta-analyses of single laboratory biomarkers.
| All PE | Pooled Sensitivity (95% CI) | Pooled Specificity (95% CI) | Area Under SROC (SE) | EOPE | Pooled Sensitivity (95% CI) | Pooled Specificity (95% CI) | Area Under SROC (SE) | LOPE | Pooled Sensitivity (95% CI) | Pooled Specificity (95% CI) | Area Under SROC (SE) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ADAM-12 (n = 3) | 0.26 (021–0.32) | 0.84 (0.82–0.86) | 0.671 (0.093) | ADAM-12 (n = 3) | - | - | - | - | - | - | - |
| Inhibin-A (n = 5) | 0.32 (0.25–0.39) | 0.90 (0.89–0.91) | 0.957 (0.046) | Inhibin-A (n = 5) | - | - | - | - | - | - | - |
| PAPP-A (n = 14) | 0.30 (0.29–0.32) | 0.92 (0.92–0.92) | 0.744 (0.071) | PAPP-A (n = 4) | 0.26 (0.19–0.34) | 0.90 (0.89–0.90) | 0.907 (0.150) | PAPP-A (n = 4) | 0.19 (0.14–0.24) | 0.89 (0.89–0.90) | 0.781 (0.173) |
| PlGF (n = 8) | 0.65 (0.63–0.67) | 0.89 (0.89–0.89) | 0.849 (0.068) | PlGF (n = 3) | 0.37 (0.27–0.48) | 0.79 (0.78–0.81) | 0.796 (0.179) | - | - | - | - |
| PP-13 (n = 9) | 0.37 (0.33–0.41) | 0.88 (0.87-0.89) | 0.882 (0.0450) | PP-13 (n = 9) | 0.59 (0.48–0.69) | 0.92 (0.91–0.93) | 0.898 (0.064) | - | - | - | - |