Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Phospholipids at plasma membranes. In normal cells, phospholipids are asymmetrically distributed between inner and outer leaflets by the function of flippase (ATP11C). During apoptosis, caspases cleave ATP11C to inactivate it, while activating Xkr8 to scramble phospholipids, thus exposing phosphatidylserine to the cell surface. In platelet activation, a high intracellular Ca2+ appears to inactivate ATP11C, while it activates TMEM16-supported phospholipid scrambling.
