Table 1. Analysed SNPs in genomic areas encompassing HGF and LOX and results of their association testing with keratoconus in Czech cases of European descendent.
| Allelic test | Dominant model | Recessive model | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Minor allele | MAF cases | MAF controls | OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value |
| rs1800449:C>T | T | 0.133 | 0.176 | 0.72 | 0.47–1.10 | 0.12 | 0.69 | 0.43–1.14 | 0.16 | 0.58 | 0.09–2.76 | 0.52 |
| rs2288393:C>G | G | 0.118 | 0.166 | 0.67 | 0.43–1.06 | 0.087 | 0.63 | 0.38–1.05 | 0.07 | 0.69 | 0.11–3.64 | 0.73 |
| rs2956540:G>C | C | 0.318 | 0.402 | 0.69 | 0.50–0.96 | 0.024 | 0.55 | 0.35–0.87 | 0.0069 | 0.78 | 0.39–1.56 | 0.52 |
| rs10519694:C>T | T | 0.200 | 0.233 | 0.82 | 0.56–1.19 | 0.32 | 0.70 | 0.45–1.10 | 0.13 | 1.59 | 0.47–5.67 | 0.43 |
| rs1014091:G>A | A | 0.152 | 0.143 | 1.08 | 0.69–1.66 | 0.75 | 1.08 | 0.66–1.76 | 0.81 | 1.17 | 0.21–6.41 | 1 |
| rs17501108:G>T | T | 0.149 | 0.145 | 1.03 | 0.66–1.59 | 0.92 | 1.04 | 0.64–1.71 | 0.90 | 0.93 | 0.18–4.42 | 1 |
| rs3735520:G>A | A | 0.458 | 0.368 | 1.45 | 1.06–1.98 | 0.018 | 1.48 | 0.94–2.36 | 0.097 | 1.86 | 1.03–3.37 | 0.036 |
Abbreviations: CI, confidence interval; MAF, minor allele frequency; OR, odds ratio; SNP, single-nucleotide polymorphism.
The effect sizes are reported with reference to the minor allele. The P-values are rounded up to the second non-zero decimal and are in bold wherever significant (<0.05). Alleles are shown aligned to the forward strand.