Table 1. Comparison of World Health Organization Disability Assessment Schedule (WHODAS) 12-item scores between the control group and each gene expanded group for the best models.

	Group differences relative to controls
	Baseline differences			Longitudinal differences
Measure (best model)	Low est. (SE)	Med est. (SE)	High est. (SE)	Low est. (SE)	Med est. (SE)	High est. (SE)
Participant 12-item Total (baseline group effect model)	0.031 (0.106)	0.224 (0.092)*	0.309 (0.087)***
Companion 12-item Total (baseline+longitudinal group effect model)	0.187 (0.106)	0.099 (0.094)	0.301 (0.091)***	−0.057 (0.099)	0.268 (0.091)**	0.269 (0.085)**

Abbreviations: Est., estimate; SE, standard error; Med, medium. Low, Medium, and High groups indicate low, medium, and high estimated probability of motor diagnosis in 5 years, respectively. ***P<0.001, **P<0.01, *P<0.05.