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. 2015 Feb 11;23(11):1538–1543. doi: 10.1038/ejhg.2015.8

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Kaplan–Meier curves for cumulative risk of thyroid cancer between patients with low compared with high KLLN promoter methylation. (a) An increased risk of thyroid cancer was observed in male patients with high KLLN promoter methylation for all cases and for PTEN mutation-negative cases. No significant differences in risk of thyroid cancer in males were observed for PTEN mutation-positive or PTEN VUS cases. (b) For females, no significant differences in thyroid cancer risk based on KLLN promoter methylation were seen for all cases, PTEN mutation-negative cases, or PTEN mutation-positive cases. A trend can be observed for increased risk for thyroid cancer with low KLLN methylation for all cases. For the PTEN VUS cases, there was a significant increase in thyroid cancer risk for females with low KLLN promoter methylation compared with high.