Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jun 1;14(14):2355–2361. doi: 10.1080/15384101.2015.1053669

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© Maria Schwaederle, Sheryl K Elkin, Brett N Tomson, Jennifer Levin Carter, and Razelle Kurzrock

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

PMC Copyright notice

Figure 3. — Squamousness signature frequency: comparison by histology. For this analysis, one point (cumulative) was given for each of the genes where abnormalities were more prevalent in squamous tumors–TP53, PIK3CA, CCND1, CDKN2A, SOX2, NOTCH1, and FBXW7– each time they were present. Because KRAS aberrations were significantly less prevalent in squamous tumors, 1 point was also assigned for the absence of KRAS. The numbers were then added up for each case. Overall, squamous cases had a median of 3 points versus only 1 point for non-squamous cases, P < 0.0001. In this bar graph, we represented the percentages of patients with ≥2 points (2 points was the median for the overall population (squamous and non-squamous cases)). All the P-values comparing squamous (blue bars) vs. non-squamous cases (red bars) were ≤0 .006. When comparing squamous tumors of a particular histology with all other squamous tumors (blue versus green bars), no significant differences were seen. For details on numbers and P-values refer to Table S2.