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Mutant p53 is suppressed by proteasome inhibitors. (A–C) MDA-MB-231 breast, MIA PaCa-2 pancreatic and DU145 prostate cancer cells were treated with the indicated concentrations of proteasome inhibitors MG132, bortezomib (Bor), carfilzomib (Car) or thiostrepton (Thio). Immunoblot analysis of HDM2, p53, p21 and β-actin as the loading control was carried out after treatment.
