Table 1. Key observed metabolic differences between the healthy adjacent thyroid and benign thyroid lesions, and between benign and malignant thyroid lesions.
| metabolite (no.) | intact thyroid tissue |
tissue aqueous extracts |
||
|---|---|---|---|---|
| Node vs Healthy n = 44, |r| > 0.29 | Malignant vs Benign n = 25, |r| > 0.39 | Node vs Healthy n = 44, |r| > 0.29 | Malignant vs Benign n = 25, |r| > 0.39 | |
| Lipid (1) | −0.65 | — | — | — |
| Citrate (36) | — | −0.59 | — | −0.79 |
| Isoleucine (2) | 0.65 | 0.41 | 0.97 | 0.57 |
| Leucine (3) | 0.67 | 0.44 | 0.96 | 0.51 |
| Valine (4) | 0.71 | 0.47 | 0.95 | 0.51 |
| Alanine (7) | 0.75 | 0.66 | 0.95 | 0.67 |
| Lysine (8) | 0.75 | 0.49 | 0.93 | 0.54 |
| Arginine (9) | 0.73 | 0.49 | 0.93 | 0.54 |
| Glutamate (11) | 0.69 | 0.60 | 0.91 | 0.45 |
| Methionine (12) | 0.85 | 0.62 | 0.96 | 0.51 |
| Glutamine (13) | 0.82 | — | 0.82 | — |
| Aspartate (14) | — | — | 0.84 | — |
| Glycine (22) | 0.78 | — | 0.90 | 0.46 |
| Tyrosine (25) | 0.73 | — | 0.97 | 0.57 |
| Phenylalanine (26) | 0.66 | 0.51 | 0.95 | 0.60 |
| Histidine (27) | — | — | 0.92 | — |
| Choline (16) | 0.63 | — | 0.84 | −0.39 |
| PC (17) | 0.79 | 0.55 | 0.97 | 0.50 |
| GPC (18) | 0.79 | 0.55 | 0.97 | 0.50 |
| PE (23) | 0.76 | 0.49 | 0.85 | 0.60 |
| Lactate (5) | 0.32 | 0.71 | 0.91 | 0.67 |
| Acetate (10) | — | — | 0.95 | — |
| Succinate (35) | — | — | 0.55 | — |
| GSH (15) | 0.48 | — | — | — |
| Taurine (19) | 0.83 | — | 0.91 | — |
| Scyllo-inositol (20) | — | −0.66 | 0.55 | −0.49 |
| Myo-inositol (21) | 0.44 | −0.87 | 0.59 | −0.46 |
| Inosine (24) | 0.65 | −0.49 | 0.67 | — |
| Uracil (29) | — | — | 0.88 | 0.42 |
| Hypoxanthine (31) | — | — | 0.82 | 0.55 |
| Xanthine (32) | — | — | 0.83 | 0.45 |
| Uridine (37) | — | −0.74 | 0.65 | −0.56 |
| Fumarate (28) | 0.29 | — | 0.50 | — |
| Formate (33) | — | — | 0.67 | — |
| U1 (38) | 0.59 | — | — | — |
The coefficients from OPLS-DA results; positive and negative signs indicate positive and negative correlation in the concentrations, respectively.