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. 2015 Apr 22;40(9):2175–2184. doi: 10.1038/npp.2015.61

Figure 3.

Figure 3

(a) Methamphetamine (MA) consumption differs by Taar1 genotype. DBA/2J (D2) mice consume more MA in mg per kg than C57BL/6J (B6) mice, as previously reported (Eastwood and Phillips, 2012). Data shown here support the greater MA consumption of MAHDR mice, compared with MALDR mice. There was a significant line × concentration interaction (F(1,122)=121.3; p<0.0001); MA intake was higher in MAHDR mice for both MA concentrations, but the difference was greater for 40 mg/l MA. Taar1 −/− mice consumed more MA than Taar1 +/− or +/+ mice. There was a genotype × concentration interaction (F(2,63)=14.4 p<0.001); MA intake differed for both MA concentrations, but the difference was greater for 40 mg/l MA. *p<0.05 for the difference between the lines or genotypes (D2 vs B6, MAHDR vs MALDR, Taar1 −/− vs Taar1 +/+ and Taar1 −/− vs Taar1 +/−) within each concentration. N=62/MADR line (49–54 days old; replicate 3, selection generation 4), and 19–28/transgenic genotype (95–365 days old). B6 and D2 data are shown here with permission (Eastwood and Phillips, 2012). MALDR: MA low drinking; MAHDR: MA high drinking. (b) Sensitivity to MA-induced conditioned taste aversion (CTA) differs by Taar1 genotype. Taar1 −/− mice were insensitive to MA-induced CTA at doses that produce CTA in Taar1 +/+ and +/− mice. There was a significant genotype × treatment × day interaction (F(8,152)=2.7 p<0.01). Subsequent analysis in MA-treated mice identified a significant genotype × day interaction (F(8,80)=4.17 p<0.0005) that was not found in saline-treated mice. Shown are means±SEM. +p<0.05 for the difference between Taar1 −/− vs Taar1 +/+ and Taar1 −/− vs Taar1 +/− on specific day; *p<0.05 for the difference in NaCl consumption on the indicated day, compared with consumption on day 7 before conditioning, within genotype, N=5–8/transgenic genotype for saline, and 7–8/transgenic genotype for MA (109–176 days old).