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. 2015 Apr 8;40(9):2269–2277. doi: 10.1038/npp.2015.76

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Copyright © 2015 American College of Neuropsychopharmacology

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NMDA receptor transmission is decreased in the CEm neurons of BDNF^Met/Met mice. (a) Frequency, amplitude, and decay time of NMDA mEPSCs in BDNF^Val/Val (9 neurons/3 mice) and BDNF^Met/Met (10 neurons/4 mice) groups. Upper panel shows examples of NMDA mEPSCs. Lower right panel shows event histogram for mEPSC amplitude. NMDA EPSC amplitude (b) and decay time (c) in BDNF^Val/Val (7 neurons/3 mice) and BDNF^Met/Met (8 neurons/3 mice) groups. Left panel shows examples of EPSCs evoked by 150 μA stimulation. (d) Paired pulse ratio of NMDA EPSCs in BDNF^Val/Val (10 neurons/4 mice) and BDNF^Met/Met (9 neurons/3 mice) groups. Asterisk denotes a statistically significant difference.