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Schematic of proposed pathomechanisms underlying microcephaly in MCPH. A premature shift from symmetric to asymmetric cell division with a subsequent depletion of the progenitor pool (left part) and proliferation defects of differentiating stem cells and cell death of proliferative cells and early postmitotic cells (right part) lead to microcephaly. Abbreviations: SC, stem cell; N, neuron; NP, neural precursor.
