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. 2014 Oct 30;13(18):2931–2943. doi: 10.4161/15384101.2014.946869

Figure 1.

Figure 1.

EVI1 and ATRA regulate gene expression both in an independent and a cooperative manner in human myeloid cells. (A) Numbers of genes significantly up- or down-regulated in response to ATRA in U937_vec cells, HL-60_vec cells, or both. (B) Numbers of genes significantly up- or downregulated in U937_EVI1 vs. U937_vec cells and in HL-60_Evi1 versus HL-60_vec cells. (C) Heatmap representing the expression (z-score) of genes whose induction by ATRA was enhanced by, or observed only in the presence of, EVI1 (category 1, CAT 1), whose repression by ATRA was counteracted by EVI1 (category 2, CAT 2), whose induction by ATRA was counteracted by EVI1 (category 3, CAT 3), and whose repression by ATRA was enhanced by, or observed only in the presence of, EVI1 (category 4, CAT 4) in U937 cells.