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. 2015 Jul 7;35(4):e00222. doi: 10.1042/BSR20150094

Table 1. Plasma biochemical parameters of patients with HHcy.

	Genetic HHcy								Acquired HHcy
Pathology	Classical homocystinuria			Cblc def.				MTHFR def.	B12 def.					N₂O ttt	Folate def.	Methotrexate ttt
Patient N°	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Age at sampling	17 Y	26 Y	31 Y	14 D	24 D	3 M	18 Y	1 D	4 M	6 M	15 Y	11 M	11Y	12 Y	4 Y	14 Y	4 Y
tHcy (μM)	262^*	631^*	322^*	127^*	211^*	154^*	89^*	155^*	124^*	90^*	122^*	125^*	111^*	155^*	59^*	40^*	31^*
Met (μM)	626^*	322^*	593^*	2^†	5^†	7^†	32	3^†	7^†	5^†	20	9^†	19^†	11^†	16^†	11^†	26
Betaine (μM)	11^†	19^†	12^†	10^†	10^†	6^†	14^†	4^†	8^†	12^†	7^†	10^†	13^†	11^†	14^†	12^†	15^†
DMG (μM)	4.0	2.4	3.9	4.0	11.8	3.0	7.0	1.0^†	8.0	9.0	22.2^*	6.0	1.6	1.3	3.6	4.1	1.9

*Concentration above the laboratory reference values according to age.

^{^†}

Concentration below the laboratory reference values according to age.

D, days, def., deficiency; M, months; Met, methionine; N₂O, nitrous oxide; tHcy, total homocysteine; ttt, treatment; Y, years.