Table 3. Genotypic associations of SNPs with HT in Jiangsu population.
| SNP | Sex | OR (95% CI) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Co-dominant | p | Dominant | p | Recessive | p | Over-dominant | p | Log-additive | p | ||
| rs16823124 | all | 0.97 (0.79–1.20) 1.02 (0.77–1.33) | 0.940 | 0.98 (0.81–1.20) | 0.880 | 1.03 (0.81–1.31) | 0.800 | 0.97 (0.80–1.17) | 0.730 | 1.00 (0.88–1.15) | 0.970 |
| female | 0.85 (0.63–1.15) 1.01 (0.68–1.51) | 0.490 | 0.89 (0.67–1.18) | 0.420 | 1.11 (0.78–1.59) | 0.560 | 0.85 (0.65–1.11) | 0.230 | 0.98 (0.80–1.19) | 0.810 | |
| male | 1.10 (0.82–1.48) 1.03 (0.71–1.49) | 0.810 | 1.08 (0.81–1.42) | 0.610 | 0.97 (0.70–1.35) | 0.860 | 1.09 (0.84–1.42) | 0.530 | 1.02 (0.85–1.23) | 0.810 | |
| rs4245739 | all | 0.85 (0.55–1.31) 0.00 (0.00–NA) | 0.410 | 0.83 (0.54–1.28) | 0.400 | 0.00 (0.00–NA) | 0.270 | 0.85 (0.55–1.31) | 0.460 | 0.82 (0.54–1.25) | 0.360 |
| female | 0.61 (0.32–1.16) NA | 0.130 | |||||||||
| male | 1.15 (0.63–2.08) 0.00 (0.00–NA) | 0.480 | 1.10 (0.61–1.98) | 0.750 | 0.00 (0.00–NA) | 0.260 | 1.15 (0.63–2.08) | 0.640 | 1.05 (0.59–1.86) | 0.860 | |
| rs2158394 | all | 1.08 (0.88-1.31) 1.08 (0.79–1.50) | 0.750 | 1.08 (0.89–1.30) | 0.440 | 1.04 (0.77–1.41) | 0.790 | 1.06 (0.88–1.28) | 0.560 | 1.05 (0.91–1.22) | 0.480 |
| female | 1.12 (0.84–1.49) 1.11 (0.71–1.73) | 0.750 | 1.11 (0.84–1.47) | 0.450 | 1.04 (0.69–1.58) | 0.850 | 1.09 (0.83–1.42) | 0.530 | 1.07 (0.87–1.31) | 0.510 | |
| male | 1.05 (0.79–1.38) 1.08 (0.68–1.71) | 0.920 | 1.05 (0.81–1.37) | 0.700 | 1.05 (0.68–1.63) | 0.830 | 1.03 (0.80–1.34) | 0.800 | 1.04 (0.85–1.28) | 0.700 | |
| rs1570105 | all | 0.87 (0.71–1.08) 0.93 (0.71–1.23) | 0.450 | 0.89 (0.73–1.09) | 0.250 | 1.01 (0.80–1.29) | 0.910 | 0.89 (0.74–1.08) | 0.250 | 0.95 (0.83–1.09) | 0.480 |
| female | 0.92 (0.68–1.25) 0.86 (0.59–1.28) | 0.750 | 0.91 (0.68–1.21) | 0.510 | 0.91 (0.64–1.28) | 0.580 | 0.97 (0.75–1.27) | 0.850 | 0.93 (0.77–1.12) | 0.450 | |
| male | 0.83 (0.62–1.12) 1.01 (0.69–1.47) | 0.360 | 0.88 (0.66–1.16) | 0.360 | 1.13 (0.81–1.58) | 0.480 | 0.83 (0.64–1.08) | 0.160 | 0.98 (0.81–1.18) | 0.830 | |
| rs2014408 | all | 1.04 (0.85–1.26) 0.76 (0.53–1.10) | 0.270 | 0.99 (0.82–1.19) | 0.890 | 0.75 (0.53–1.07) | 0.110 | 1.07 (0.89–1.30) | 0.470 | 0.94 (0.81–1.09) | 0.430 |
| female | 1.03 (0.78–1.36) 0.74 (0.44–1.24) | 0.460 | 0.98 (0.75–1.28) | 0.860 | 0.73 (0.44–1.21) | 0.220 | 1.07 (0.81–1.41) | 0.630 | 0.93 (0.75–1.15) | 0.520 | |
| male | 1.05 (0.80–1.38) 0.80 (0.48–1.32) | 0.570 | 1.00 (0.77–1.31) | 0.970 | 0.78 (0.48–1.27) | 0.320 | 1.08 (0.83–1.41) | 0.560 | 0.96 (0.78–1.18) | 0.690 | |
| rs33063 | all | 0.89 (0.67–1.19) 2.16 (0.19–23.92) | 0.600 | 0.91 (0.68–1.20) | 0.490 | 2.19 (0.20–24.24) | 0.510 | 0.89 (0.67–1.19) | 0.440 | 0.92 (0.70–1.21) | 0.550 |
| female | 0.74 (0.49–1.10) NA | 0.140 | |||||||||
| male | 1.07 (0.71–1.61) 2.30 (0.21–25.47) | 0.740 | 1.09 (0.73–1.63) | 0.660 | 2.28 (0.21–25.25) | 0.490 | 1.07 (0.71–1.60) | 0.750 | 1.11 (0.76–1.63) | 0.590 | |
| rs7297416 | all | 1.07 (0.88–1.32) 1.04 (0.77–1.40) | 0.790 | 1.07 (0.88–1.30) | 0.520 | 0.99 (0.76–1.31) | 0.970 | 1.06 (0.88–1.28) | 0.520 | 1.03 (0.90–1.19) | 0.660 |
| female | 1.12 (0.83–1.49) 1.07 (0.70–1.61) | 0.770 | 1.10 (0.84–1.46) | 0.490 | 1.00 (0.68–1.46) | 0.990 | 1.10 (0.84–1.43) | 0.500 | 1.05 (0.86–1.28) | 0.620 | |
| male | 1.04 (0.78-1.38) 1.01 (0.65–1.56) | 0.970 | 1.03 (0.78–1.36) | 0.830 | 0.99 (0.66–1.47) | 0.950 | 1.03 (0.80–1.35) | 0.800 | 1.01 (0.83–1.24) | 0.900 | |
| rs59251428 | all | 1.06 (0.87–1.29) 0.98 (0.67–1.43) | 0.800 | 1.05 (0.87–1.27) | 0.600 | 0.95 (0.66–1.38) | 0.800 | 1.07 (0.88–1.29) | 0.510 | 1.02 (0.88–1.19) | 0.750 |
| female | 0.81 (0.61–1.08) 1.15 (0.67–1.95) | 0.240 | 0.86 (0.65–1.12) | 0.260 | 1.26 (0.75–2.11) | 0.380 | 0.80 (0.61–1.05) | 0.110 | 0.94 (0.76–1.17) | 0.590 | |
| male | 1.37 (1.04–1.80) 0.83 (0.48–1.44) | 0.035 | 1.28 (0.99–1.67) | 0.061 | 0.71 (0.42–1.23) | 0.220 | 1.40 (1.08–1.83) | 0.012 | 1.12 (0.90–1.38) | 0.300 | |
| rs3858313 | all | 0.92 (0.75–1.13) 0.86 (0.64–1.15) | 0.540 | 0.91 (0.75–1.10) | 0.320 | 0.90 (0.69–1.17) | 0.430 | 0.96 (0.80–1.16) | 0.670 | 0.93 (0.81–1.06) | 0.270 |
| female | 1.04 (0.78–1.39) 0.92 (0.61–1.39) | 0.820 | 1.01 (0.77–1.33) | 0.930 | 0.90 (0.61–1.32) | 0.580 | 1.07 (0.82–1.40) | 0.640 | 0.98 (0.81–1.19) | 0.830 | |
| male | 0.82 (0.61–1.08) 0.81 (0.54–1.22) | 0.330 | 0.82 (0.62–1.07) | 0.140 | 0.91 (0.62–1.32) | 0.610 | 0.86 (0.66–1.12) | 0.270 | 0.88 (0.73–1.06) | 0.190 | |
| rs4746172 | all | 0.96 (0.79–1.18) 0.86 (0.65–1.15) | 0.590 | 0.94 (0.77–1.14) | 0.510 | 0.88 (0.68–1.14) | 0.340 | 1.00 (0.83–1.21) | 0.960 | 0.94 (0.82–1.07) | 0.340 |
| female | 1.31 (0.98–1.75) 1.11 (0.74–1.67) | 0.190 | 1.26 (0.95–1.65) | 0.100 | 0.96 (0.66–1.40) | 0.830 | 1.27 (0.97–1.66) | 0.081 | 1.11 (0.91–1.35) | 0.300 | |
| male | 0.71 (0.53–0.95) 0.68 (0.46–1.01) | 0.039 | 0.70 (0.54–0.92) | 0.011 | 0.82 (0.57–1.18) | 0.280 | 0.80 (0.61–1.04) | 0.091 | 0.80 (0.66–0.97) | 0.020 | |
OR, Odds ratio; 95% CI, 95% confidence interval. For total samples, p values were adjusted by sex and age, and for sex subgroup analyses, p values were adjusted by age. P values < 0.05 were marked in bold.