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. 2015 Jul 14;35(4):e00227. doi: 10.1042/BSR20140122

Figure 4. Perivascular pre-treatment with antioxidants significantly reduces early-onset apoptosis and shows a trend towards attenuation of NIH.

Figure 4

(A–C) Detection of apoptotic VSMC at 90 min post injury in arteries that were pre-treated with either vehicle (A), VAS2870 (B) or PEG-SOD (C) using In Situ Oligo Ligation (brown) to detect apoptotic nuclei. Representative apoptotic VSMC are shown by arrows. Scale bar=30 μm. (D) Quantification of apoptotic cells per high power field (HPF) in injured arteries pre-treated with antioxidants or vehicle and harvested at 90 min post injury. Values are represented as the mean ± S.E.M. (n=3–4), P< 0.05. (E) Neointima-to-media thickness ratio at 30 days post injury in arteries that were pre-treated with antioxidants or vehicle. Values are represented as the mean ± S.E.M. (n=4–6).