Table 2. Pharmacokinetic parameters of CR-SPRC and SPRC in normal and MI rats (mean ± S.D., n=6).

Parameters	SPRC	CR-SPRC	MI+SPRC	MI+CR-SPRC
Cmax (μg/ml)	31.65±1.73	26.10±3.68*	27.75±1.89†	21.02±2.37*‡
Tmax (h)	0.8±0.3	2.7±1.0*	0.8±0.3	2.7±1.0*
AUC(0–t) (mg/l h)	100.7±11.1	122.7±16.0§	67.4±7.7†	102.0±14.0*‡
MRT (0–t) (h)	2.8±0.4	3.4±0.3§	2.5±0.5	3.5±0.3*
Tlast (h)	12.0±2.5	12.0±1.8	17.3±5.2‡	28.0±3.1*║

*P< 0.01 SPRC compared with CR-SPRC or MI + SPRC compared with MI + CR-SPRC.

^†P< 0.01 SPRC compared with MI + SPRC.

^‡P< 0.05 CR-SPRC compared with MI + CR-SPRC.

^§P< 0.05 SPRC compared with CR-SPRC or MI + SPRC compared with MI + CR-SPRC.

^║P< 0.01 CR-SPRC compared with MI + CR-SPRC.