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CGGBP1-mediated regulation of global transcription by Pol II. (top) In quiescent cells (or under heat shock), Alu is transcribed by Pol III. The Alu RNA binds to RNA Pol II to inhibit the transcriptional activity. (bottom) Upon growth stimulation by extracellular signals, CGGBP1 becomes phospholylated and binds to the Alu sequences to interfere the Pol III recruitment. Accordingly, the Alu RNA level is decreased and the Pol II genes become more activated.
