Table 1.
Major integrase RAMs detected in raltegravir recipients with viraemia
| RAMs, n (%)a |
Pattern, n (%)b | |||||
|---|---|---|---|---|---|---|
| E92Q, 9 (3.5) | G140S/A, 37 (14.5) | Y143R/C/H, 14 (5.5) | S147G, 1 (0.4) | Q148H/R/K, 44 (17.3) | N155H, 57 (22.4) | |
| X | 45 (17.6) | |||||
| X | X | 35 (13.7) | ||||
| X | 12 (4.7) | |||||
| X | X | 8 (3.1) | ||||
| X | 6 (2.4) | |||||
| X | X | 2 (0.8) | ||||
| X | X | 1 (0.4) | ||||
| X | X | 1 (0.4) | ||||
| X | X | X | 1 (0.4) | |||
| X | 1 (0.4) | |||||
| X | 1 (0.4) | |||||
aOverall 113/255 (44.3%) raltegravir recipients had one or more major RAMs. The mutations observed were: E92Q (n = 9); G140S (n = 33) and G140A (n = 4); Y143R (n = 9), Y143C (n = 4) and Y143H (n = 1); Q148H (n = 28), Q148R (n = 15) and Q148K (n = 1); and N155H (n = 57).
bX symbols within each row indicate mutations present in each pattern.