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. Author manuscript; available in PMC: 2016 Feb 24.
Published in final edited form as: ACS Nano. 2015 Feb 10;9(2):1108–1116. doi: 10.1021/acsnano.5b00067

Figure 1. Construction of multi-module pRNA nanoparticles for CRC metastasis targeting.

Figure 1

a. 2D sequence of pRNA 3WJ domain composed of three RNA oligomers (a, b, c), folic acid (FA) and near-infrared fluorescent dye Alexa647 (left); 3D model and AFM images of pRNA 3WJ motif harboring monomeric pRNA as functional modules. b. The most common sites of CRC metastasis—liver, lung and lymph nodes. The FA-conjugated pRNA (FA-pRNA) nanoparticle targets FRα positive tumors upon systemic administration. c. CRC liver, lung and lymph node experimental metastasis modes (Green: metastatic tumors)