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. Author manuscript; available in PMC: 2016 Feb 24.
Published in final edited form as: ACS Nano. 2015 Feb 10;9(2):1108–1116. doi: 10.1021/acsnano.5b00067

Figure 3. FA-pRNA nanoparticles binding to CRC cells.

Figure 3

a. Binding and entry of FA-pRNA-Alexa647 nanoparticles into KM20 and HT29 cells in vitro. Magnification 40×. b. Single dose (4μg/g in 100 μl of PBS) of FA-pRNA-Alexa647 labeled nanoparticles was administered intravenously into mice with HT29 liver metastases. Accumulation of fluorescently-labeled nanoparticles was evaluated microscopically 2h after RNA nanoparticle administration. Yellow arrow: pRNA-Alexa647 (top panel), FA-pRNA-Alexa647 (bottom panel); green: GFP-expressing cancer cells; blue: DAPI stain for nuclear dsDNA; magenta: Alexa647. Magnification 40×.