Table 3. Changes in baseline RSNA (%) and MAP (mmHg) in response to the microinjection of saline, L-NAME (100 nmol), SNP (50 nmol), Nω-propyl (5 nmol), L-NIO (50 nmol) or SMT (500 pmol) into the PVN of the Control and IR rats.
| Control | IR | |
|---|---|---|
| Saline; L-NAME (ΔRSNA) | 0.62±0.94; 21.3±2.7* | 0.58±1.11; 10.0±2.1* , # |
| Saline; L-NAME (ΔMAP) | 0.50±1.06; 11.7±1.0* | -0.31±1.24; 5.8±1.0* |
| Saline; SNP (ΔRSNA) | 0.62±0.94; -19.2±1.9* | 0.58±1.11; -8.9±1.3* , # |
| Saline; SNP (ΔMAP) | 0.50±1.06;–12.2±2.0* | -0.31±1.24; -8.5±1.8* |
| Saline; Nω-propyl (ΔRSNA) | 0.62±0.94; 16.0±2.4* | 0.58±1.11; 8.1±1.3* , # |
| Saline; Nω-propyl (ΔMAP) | 0.50±1.06; 9.3±1.5* | -0.31±1.24; 4.7±1.3* , # |
| Saline; L-NIO (ΔRSNA) | 0.62±0.94; 9.8±1.4* | 0.58±1.11; 3.7±0.8* , # |
| Saline; L-NIO (ΔMAP) | 0.50±1.06; 4.8±0.9* | -0.31±1.24; 1.3±0.9 # |
| Saline; SMT (ΔRSNA) | 0.62±0.94; 0.95±1.03 | 0.58±1.11; 0.05±1.30 |
| Saline; SMT (ΔMAP) | 0.50±1.06; 0.36±1.31 | -0.31±1.24; 0.13±1.00 |
The values are expressed as the means±SE. n = 6 for each group.
*P<0.05 vs. saline.
#P<0.05 vs. the Control group.
PVN: paraventricular nucleus; RSNA: renal sympathetic nerve activity; MAP: meanarterial pressure; IR: insulin resistance. For each side of the PVN, the microinjection volume was 50 nL for each chemical used in this study. Baseline RSNA and MAP were determined based on a 2-min average of their maximal response after PVN microinjection.