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. 2015 Jun 30;14(16):2561–2565. doi: 10.1080/15384101.2015.1066538

Table 1.

Cellular Process/ Organelle Functions Effect of GIV's GEF function Citation
Cell Migration “ON” = Enhances, “OFF” = Inhibits 4,10-16
Golgi Structure and Secretory Function “ON” = Preserves and enhances, “OFF” = Disrupts, delays 8
Autophagy “ON” = Halt and rescue, “OFF” = Initiate and promote 7
Endosome Maturation “ON” = Rapid, “OFF” = Slowed 17
Cell Survival “ON” = Survive, “OFF” = Apoptosis 14,18
Cell Polarity “ON” = Polarity achieved, “OFF” = Loss of polarity 19,37
Cell Division Not examined 20
Endocytosis Not examined 21
Cell-cell Junctions, Permeability Not examined 22
Neuronal Migration and Differentiation Not examined 23,24
Macrophage Chemotaxis Not examined 12
Cell Size Not examined 25