Figure 2.

Evaluation of HSC/Ps in young and aged WT and Fanca^−/− mice. Absolute cell counts per femur of (A) committed progenitors: Lineage⁻, c-Kit⁺, Sca-1⁻ (LK(S-)); (B) HSCs and MPPs: Lineage⁻, c-Kit⁺, Sca-1⁺ (LSK); (C) MPPs: Lineage-, c-Kit⁺, Sca-1⁺, CD48⁺ and; (D) LT-HSCs: Lineage-, c-Kit⁺, Sca-1⁺, CD48⁻, CD150⁺, CD34⁻ in 0.5, 1 and 2 y old WT and Fanca^−/− mice. Mean ± s.d is shown for n = 3 −6 mice per group. *p < 0.05, ** p < 0.01, not significant (ns) = p > 0.05, unpaired t-test.