Figure 3.

Extended time-course analysis of incidence of SAA in Fanca^−/− mice in response to chronic inflammatory stress. (A) Schematic representation of the pI:pC treatment schedule which was repeated up to 8 times. (B) Cumulative BMF expressed as percentage in WT and Fanca^−/− mice. n = 12 mice were analyzed in the WT and Fanca^−/− control groups, and n = 18 mice were included in both WT and Fanca^−/− pI:pC treated groups. Statistical significance was assessed by log-rank (Mantel-Cox) test. ***p < 0.001. (C) Representative hematoxylin and eosin staining of femoral sections from WT or Fanca^−/− mice after cessation of treatment. (D) Peripheral blood cell count analysis of the WT and Fanca^−/− control groups after cessation of treatment, and the Fanca^−/− pI:pC treated group at the time the mice displayed SAA. White blood cell = WBC, Platelet = PLT. Individual mice are represented with circles and mean ± s.d is shown. *=p < 0.05, ***=p < 0.001, non significant (ns) = p > 0.05, unpaired t-test. Data comprises an extended time course of experiments originally published in.¹