Figure 5.

DCA decreases tumor size in medulloblastoma allograft models. (A) MB neurospheres were injected into the flanks of athymic mice and DCA (1.4 g/l) was administered in the drinking water. Measures were performed when tumors reached a measurable volume (day 0). (B) Representative images of tumors at the end of the treatment. Tumor size was measured by calipers in vivo and after euthanasia. *DCA versus vehicle, P < 0.05. (C) Local L-lactate concentration in tumors from vehicle-treated and DCA-treated groups. Values were normalized for tissue weight (mg) and expressed as fold change relative to control. Data represents the average −/+ SD of 3 independent experiments. *DCA versus vehicle, P < 0.05 n = 3. (D) Immunohistochemistry of Ki67 and Caspase 3 expression in tumor sections from vehicle and DCA-treated mice.