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. 2014 Oct 30;13(20):3282–3291. doi: 10.4161/15384101.2014.954454

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Association of RNA levels of PER2, PER3, CRY2 and TIMELESS with clinical parameters. Significant associations (P < 0.05) of PER2 (205251_at), PER3 (221045_s_at) and CRY2 (212695_at) with positive estrogen receptor (ER) status, lower grade, lack of metastasis, lower pT stage (1) and higher age were obtained. In addition, PER3 and CRY2 also associate with negative HER2-status. TIMELESS (203046_s_at), in contrast, showed significant association with negative ER-status, positive HER2-status higher grade, higher pT stage (2+3) and early metastasis. Differences for age, ER status, HER2 status, pTstage and metastasis were tested by the Mann-Whitney test, differences between grading by the Kruskal-Wallis test. The analysis included 766 patients with node negative breast carcinoma. Further analyses are shown in Fig. S4.