Fig. 8.

Residues in the ligand-binding domains of rat and human α3 and α6 subunits are only partially conserved between the two species. A sequence comparison of amino acids 150–200 of rat and human α3 and α6 ligand-binding domains was performed. Residues marked with the asterisk and numbered 152, 184, and 195 are important for α-Ctx binding. Note that residue 152 is conserved between rat and human α3 subunits, but not residues 184 and 195.