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α-Ctx AuIB inhibits human α6/α3β4 nAChRs more potently that α3β4 nAChRs. Oocytes expressing α6/α3β4 or α3β4 nAChR subtypes were subjected to two-electrode voltage-clamp electrophysiology, as described in Materials and Methods. AuIB inhibited α6/α3β4 nAChRs with an IC50 value of 360 (305–424) nM (n = 4) and α3β4 nAChRs with an IC50 value >10 μM (n = 4). The error bars denote the S.E.M., and the values in parentheses denote the 95% confidence interval.
