TABLE 1.

Sequence comparison of select α-Ctxs and their selectivity profiles

	Amino Acid Sequence	nAChR Potency	Reference
α-Conotoxin
LvIA	GCCSHPACNVDHPEIC	α3β2 > α3β4; α6/α3β2β3 = α6/α3β4	(Luo et al., 2014)
TxIB	GCCSDPPCRNKHPDLC	α6/α3β2β3 > >α3β2,α3β4,α6/α3β4	(Luo et al., 2013)
PnIA	GCCSLPPCAANNPDYC	α3β2 > >α3β4; α6/α3β2β3 > α6/α3β4	(Luo et al., 1999)
LvIA(N9R,V10A)	GCCSHPACRADHPEIC	α3β2 > >>α3β4; α6/α3β2β3 > >α6/α3β4	This work

>, 2- to 99-fold; > >, 100- to 500-fold; > >>, >1000-fold.

Residues shaded are conserved between the four peptides, and residues bolded are those substituted from TxIB and PnIA.