TABLE 2.
IC50 values for inhibition of human nAChRs expressed in Xenopus oocytes and adrenal chromaffin cell nAChRs
| BuIA(T5A,P6O) | LvIA(N9R,V10A) | PeIA(A7V,S9H,V10A,N11R,E14A) | |
|---|---|---|---|
| α3β2 | >10 μM | 3.3 (2.4–4.7) nM | 6.1 (3.6–10.3) µM |
| α3β4 | 166 (141–196) nM | >10 μM | 3.7 (2.4–5.8) µM |
| β4α3β4α3α5(D) | 147 (125–173) nM | >10 μM | 9.2 (6.4–13.4) µM |
| α4β2 | >10 μM | 195 (133–284) nM | >10 μM |
| α4β4 | >10 μM | >10 μM | >10 μM |
| α6/α3β2β3 | >10 μM | 13.5 (8.6–21.2) nM | 3.8 (3.2–4.5) nM |
| β3α6β2α4β2 | >10 μM | 11.4 (8.1–16.0) nM | 6.3 (5.6–7.1) nM |
| α6/α3β4 | 7.4 (6.5–8.3) nM | 1.0 (7.5–13.3) µM | N.D. |
| α6M211L,cytα3β4 | 11.3 (10.1–12.7) nM | 2.8 (2.5–3.3) μM | 1.6 (1.2–2.2) nM |
| ACC | 46.7 (39.8–55.1) nM | >1 μM | >1 μM |
ACC, adrenal chromaffin cells.
Values in parentheses indicate the 95% confidence interval.