TABLE 4.

Pharmacokinetics profile of PDE9 inhibitor C33

Dosing Route	T1/2	Tmax	Cmax	AUC0-t	AUC0-inf	MRTinf	Vz	CLz	F
	hour	hour	ng/ml	ng/h/ml	ng/h/ml	hour	l/kg	l/h/kg	%
By mouth	1.5 ± 0.2	2.0 ± 0.0	372 ± 6	1600 ± 300	1700 ± 300	3.5 ± 0.3	NA	NA	56.5
i.v.	1.4 ± 0.1	0.02 ± 0.00	5300 ± 900	3000 ± 200	3100 ± 200	1.6 ± 0.2	3.2 ± 0.1	1.6 ± 0.1

AUC, area under the curve; Cl, clearance; MRT, mean residence time; NA, not applicable.