Fig. 4.

Stool output, rate of fecal neutral sterol excretion, plasma total cholesterol concentration, and whole animal cholesterol content in Lal^+/+ and Lal^−/− mice given PRD125. These data were derived from the same mice used for the measurements described in Figs. 2 and 3. Starting 4 days before the study, stools were collected from each mouse for the measurement of the rate of fecal neutral sterol excretion. Whole body cholesterol contents were determined by summing the quantity of cholesterol within the liver and small intestine with those present in all of the other organs combined. Values are the mean ± S.E.M. of data from five animals in each group. Different letters denote statistically significant (P < 0.05) differences between values, as determined by two-way analysis of variance, with genotype and treatment as the variables.