TABLE 1.

Characteristics of lysosomal acid lipase-deficient female mice at different stages of disease progression.

Data are presented as mean ± S.E.M. of values in four mice per group. All mice were weaned at 21 days of age and thereafter fed a basal rodent chow diet ad libitum. They were studied in the fed state.

	Age
	21 days		49–51 days		140–142 days
	Lal+/+	Lal−/−	Lal+/+	Lal−/−	Lal+/+	Lal−/−
Body weight (g)	10.6 ± 0.6	10.3 ± 0.4	20.8 ± 0.3	20.8 ± 0.5	26.1 ± 0.5	24.2 ± 1.1
Liver weight (g)	0.53 ± 0.04	0.64 ± 0.02	1.07 ± 0.04	2.32 ± 0.10*	1.08 ± 0.04	4.93 ± 0.26*
Hepatic esterified cholesterol concentration (mg/g)	1.0 ± 0.3	30.0 ± 0.6*	0.4 ± 0.1	56.3 ± 3.8*	0.8 ± 0.1	53.7 ± 2.3*
Hepatic unesterified cholesterol concentration (mg/g)	2.1 ± 0.1	2.7 ± 0.1*	2.0 ± 0.1	3.2 ± 0.1*	2.0 ± 0.1	6.8 ± 0.5*
Whole-liver cholesterol content (mg/organ)	1.7 ± 0.2	20.8 ± 1.0*	2.6 ± 0.1	138.1 ± 11.3*	3.0 ± 0.2	297 ± 10.7*
Hepatic triacylglycerol concentration (mg/g)	7.2 ± 2.0	10.2 ± 1.8	6.0 ± 0.7	14.6 ± 0.6*	12.6 ± 1.5	19.4 ± 0.8*
Whole-liver triacylglycerol content (mg/organ)	3.9 ± 1.1	6.5 ± 1.3	6.5 ± 0.8	40.0 ± 2.8*	13.6 ± 1.9	97.4 ± 10.6*
Plasma ALT activity (units/l)	32 ± 2	39 ± 5	33 ± 2	268 ± 37*	28 ± 4	617 ± 97*

^*P < 0.05 compared with corresponding Lal^+/+ mice of the same age.