Table 1.

V_m values recorded in WT and TALK-1 KO β-cells

Recording conditions	Interburst (electrically silent) Vm (mV)	Plateau Vm (mV)
2 mmol/L glucose
WT	−72.7 ± 1.2 (n = 12)	n.a.
TALK-1 KO	−65.13 ± 0.66 (n = 13)	n.a.
Statistical significance	***	n.a.
7 mmol/L glucose
WT	−64.7 ± 2.4 (n = 9)	−49.7 ± 1.7 (n = 8)
TALK-1 KO	−55.7 ± 1.1 (n = 6)	−47.3 ± 0.8 (n = 9)
Statistical significance	**	n.s.
11 mmol/L glucose
WT	−70.6 ± 2.5 (n = 9)	−51.2 ± 1.6 (n = 12)
TALK-1 KO	−62.7 ± 2.1 (n = 12)	−44.2 ± 0.9 (n = 13)
Statistical significance	*	***
14 mmol/L glucose
WT	−63.1 ± 2.0 (n = 7)	−46.3 ± 2.2 (n = 7)
TALK-1 KO	−54.6 ± 2.1 (n = 7)	−41.1 ± 0.9 (n = 7)
Statistical significance	*	*

Data are means ± SEM unless otherwise indicated. The V_m of β-cells in intact WT and TALK-1 KO was measured under the conditions described in the table. N observations were made from 5 islet preparations per genotype. n.a., not applicable; n.s., no significant difference.

*P < 0.05;

**P < 0.005;

***P < 0.0005.