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. 2015 Feb 19;14(8):1164–1173. doi: 10.1080/15384101.2015.1010866

Figure 5.

Figure 5.

Effects of CDK4 inhibition on the senescence phenotype. (A) Representative images of SVts8 cells at the permissive temperature (34°C) or after shifting to the non-permissive temperature (39°C) in the presence or absence of the CDK4 inhibitor PD0332991 (4μM). The cells were stained with DAPI. (B) Mean cell size comparisons of SVts8 at the non-permissive temperature in the presence or absence of the CDK4 inhibitor PD0332991. (C) Cell cycle profiles of SVts8 cells at 34°C or 39°C in the presence or absence of the CDK4 inhibitor PD0332991. (D) Mean cell size comparisons of SVts8 at 34°C or after shifting to 39°C in either 0.2% or 10% serum.