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Intracellular NAD levels, PARP1 levels and activity in non-mutated and BRCA1-mutated breast cancer. (A—C) NAD and NADH levels, and the NAD/NADH ratio were measured in 41 pairs of non-mutated and BRCA1-mutated breast cancer and their adjacent normal tissue. (D—F) PARP1 protein and mRNA levels, and PARP1 activity were measured in 41 pairs of non-mutated and BRCA1-mutated breast cancer samples and the adjacent normal tissue. Bar graphs show mean ± SD.
