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. 2014 Nov 18;13(24):3798–3807. doi: 10.4161/15384101.2014.987627

Figure 4.

Figure 4.

Summary of mouse strains with different levels of p53 activity and associated phenotypes. Mouse strains manifesting varying levels of p53 stabilization and/or activity exhibit diverse phenotypes ranging from embryonic lethality to premature aging to increased tumor susceptibility. The phenotypes and the p53 status in each indicated mouse strain are described.87-89