Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Nov 11;13(23):3628–3635. doi: 10.4161/15384101.2014.985507

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Taylor & Francis Group, LLC

PMC Copyright notice

Figure 4. — Arrest-Geroconversion model. Schematic representation of types of senescence (Arrest- red stop sign. Geroconversion – green arrow). (A) Typical arrest-induced senescence. DNA damage-induced senescence. CDK (p21 and 16)–induced senescence. (B) In the presence of rapamycin: geroconversion is slowed down and extended. (C) Oncogene-induced senescence. Oncogenes such as Ras empower growth, cause arrest and then empower geroconversion. (D) Replicative senescence of human cells in culture. Telomere shortening during cell proliferation eventually causes Arrest. Then geroconversion ensures senescence. (E) Replicative senescence of rodent cells in culture. Ovestumulation of mTOR by mitogen/nutrient/oxygen rich medium causes cellular hypertrophy.