Figure 1.
SMYD1 and G6PD are, respectively, among the top upregulated and downregulated genes following miR-206-induced ERMS cell differentiation and are differentially expressed in primary tumors compared to normal muscle. (A) Top 30 up-regulated genes and top 70 down-regulated genes in RD18 ERMS cells conditionally expressing miR-206 (RD18 NpBI-206 IND).9 SMYD1 is indicated with a red bar, G6PD is indicated with a blue bar. (B and C) Levels of expression of SMYD1 and G6PD mRNAs in human skeletal muscle (SM) and primary RMS tumors. ****P <0.0001 and **P<0.01. The publicly available datasets used for this analysis are specified in the Material and Methods section.