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Model of the CGGBP1-Alu RNA pathway. In serum starved cells, CGGBP1 is pan-cellular, Alu SINEs are transcribed by Pol III, and Alu RNA represses Pol II transcription. Upon serum activation, CGGBP1 is phosphorylated, becomes nuclear, binds to Alu SINEs, and blocks Pol III transcription. The resulting decrease in Alu RNA levels results in active Pol II transcription.
