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Possible mechanisms of action. The figure illustrates three possible mechanisms whereby SSRIs might improve structural‐brain tissue recovery from ischemia: stimulation of neurogenesis in the subependymal zone and hippocampal dentate gyrus, inhibition of microglia‐ and neutrophile‐induced inflammation mediated by cytotoxic inflammatory molecules, and improvement of cerebral vascular autoregulation (HO‐1, heme oxygenase‐1; VEGF, vascular endothelial growth factor).
