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. 2015 Oct 21;5:15419. doi: 10.1038/srep15419

Figure 8. Kainic acid-induced lesion of the medial septal region attenuated contextual fear.

Figure 8

In (a), freezing response was reduced in ‘KA’ group vs. ‘Sham’ group. ‘KA’ and ‘Sham’ groups were pre-treated with microinjection of kainic acid and vehicle, respectively, into the medial septal region. The effect of KA pre-treatment on populations of neurons in the MSDB is shown in Fig. 4. The different groups of animals were either conditioned with 3 footshocks (‘3 shocks’ on the figure) or did not receive any shock (‘No shock’ on the figure). Interestingly, KA pre-treatment did not attenuate acute reaction to footshock. Indeed, acute reaction, as measured by maximum velocity recorded during footshock, was enhanced in ‘KA’ group as compared to ‘Sham’ group (b). Data are mean ± SEM. Statistical significance: (a) *p < 0.05 vs. other groups; #p < 0.05 vs. Sham No shock and KA No shock; (b) ***p < 0.001 vs. Sham. Statistical analyses were performed using one-way ANOVA (a) or unpaired t-test (b).