Figure 1.

SIRT1 regulates KSHV life cycle. High NAD⁺ level promotes viral latency by activating SIRT1, resulting in the silencing of the RTA promoter and inhibition of RTA transactivation of downstream targets. Low NAD⁺ level disrupts viral latency by inhibiting SIRT1 function resulting in the induction of RTA expression and KSHV lytic replication program.