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CAF reprogramming using MFAP5-tareting siRNA delivered by chitosan nanoparticles significantly reduces the level of CAF-derived MFAP5 protein in the tumor microenvironment. Shutting down MFAP5-modulated activation of αvβ3 integrin and subsequent calcium-dependent FAK/CREB/TNNC1 signaling result in the inhibition of ovarian cancer metastasis.
