Table 1.
Clinical characteristics of 125 patients with initial stage IV gastric cancer
| Variable | Arm A1a) (n=58) | Arm B1a) (n=33) | p-valueb) |
|---|---|---|---|
| Median age (yr) | 43.3 (26-69) | 42.1 (27-72) | 0.428 |
| < 50 | 39 (80.0) | 64 (84.2) | 0.508 |
| ≥ 50 | 10 (20.4) | 12 (15.8) | - |
| Laterality | 0.315 | ||
| Bilateral | 37 (75.5) | 51 (67.0) | - |
| Unilateral | 12 (24.5) | 25 (33.0) | - |
| Krukenberg tumor size (cm) | 7.99 (3.4-19) | 5.76 (1.5-24) | 0.004 |
| Pathologic differentiation | 0.236 | ||
| WD-MD | 7 (14.3) | 6 ( 7.9) | - |
| PD-SRC | 42 (85.7) | 69 (90.8) | - |
| Chronology | 0.676 | ||
| Synchronous | 34 (69.3) | 50 (65.8) | - |
| Metachronous | 15 (30.6) | 26 (34.2) | - |
| Metastasis site | |||
| Peritoneum | 38 (77.6) | 66 (86.8) | 0.175 |
| Liver | 6 (12.2) | 10 (13.2) | 0.881 |
| Bone | 5 (10.2) | 11 (14.4) | 0.723 |
| Lung | 2 (4.1) | 5 (6.6) | 0.704 |
| Other | 23 (46.9) | 32 (42.1) | 0.699 |
| Extent of disease | 0.028 | ||
| Limited to the ovary | 7 (14.3) | 2 (2.6) | - |
| Beyond the ovary | 42 (85.7) | 74 (97.4) | - |
| R status | |||
| R0 resection | 14 (28.6) | - | - |
| R2 resection | 35 (71.4) | - | - |
| Serum CEA (ng/mL) | 3.05 (0.01-36.3) | 5.80 (0.01-121) | 0.277 |
| Normal | 41 (83.7) | 56 (73.7) | 0.083 |
| > 5 | 4 (8.2) | 15 (19.7) | - |
| Serum CA 19-9 (U/mL) | 96.64 (0.1-1,850) | 484.5 (0.1-12,100) | 0.067 |
| Normal | 32 (65.3) | 30 (39.5) | 0.009 |
| > 24 | 14 (28.6) | 37 (48.7) | - |
| Serum CA-125 (U/mL) | 74.1 (5.5-244) | 187 (11-1,555) | 0.051 |
| Normal | 14 (28.6) | 11 (14.5) | 0.159 |
| > 35 | 14 (28.6) | 23 (30.3) | - |
Values are presented as median (range) or number (%). WD-MD, well differentiated adenocarcinoma and moderately differentiated adenocarcinoma; PD-SRC, poorly differentiated adenocarcinoma and signet ring cell carcinoma; CEA, carcinoembryonic antigen; CA, cancer antigen.
a)
Patients were divided into two arms according to treatment modality: arm A, metastasectomy plus chemotherapy; arm B, chemotherapy alone,
b)
p-values from chi-square test except for Krukenberg tumor size, and median age at Krukenberg tumor diagnosis, which were determined by a two-tailed Student t test.