Table 2.
Clinical characteristics of 91 patients with recurrent Krukenberg tumor
| Variable | Arm A2a) (n=58) | Arm B2a) (n=33) | p-valueb) |
|---|---|---|---|
| Median age (yr) | 43.9 (21-78) | 45.9 (25-75) | 0.372 |
| < 50 | 41 (70.7) | 18 (54.5) | 0.121 |
| ≥ 50 | 17 (29.3) | 15 (45.5) | - |
| Relapse free survival (mo) | 24.3 (3-109) | 27.8 (4-91) | 0.435 |
| Laterality | 0.022 | ||
| Bilateral | 42 (72.4) | 16 (48.5) | - |
| Unilateral | 16 (27.6) | 17 (51.5) | - |
| Krukenberg tumor size (cm) | 7.39 (3-18) | 5.95 (1.9-15) | 0.068 |
| Pathologic differentiation | 0.499 | ||
| WD-MD | 6 (10.3) | 5 (15.2) | - |
| PD-SRC | 52 (89.7) | 28 (84.8) | - |
| AJCC stage | 0.824 | ||
| I, II | 26 (44.8) | 14 (42.4) | - |
| III | 32 (55.2) | 19 (57.6) | - |
| Metastasis site | |||
| Peritoneum | 45 (77.6) | 26 (78.8) | 0.894 |
| Liver | 4 (6.9) | 4 (12.1) | 0.454 |
| Bone | 6 (10.3) | 5 (15.2) | 0.519 |
| Lung | 2 (3.4) | 0 (0) | 0.533 |
| Other | 33 (56.9) | 13 (39.4) | 0.108 |
| Extent of disease | 0.25 | ||
| Limited to the ovary | 7 (12.1) | 1 (3.0) | - |
| Beyond the ovary | 51 (87.9) | 32 (97.0) | - |
| R status | |||
| R0 resection | 27 (46.6) | - | - |
| R2 resection | 31 (53.4) | - | - |
| Serum CEA (ng/mL) | 2.79 (0.13-22.2) | 332 (0.65-10,410) | 0.319 |
| Normal | 44 (75.9) | 24 (72.7) | 0.276 |
| > 5 | 8 (13.8) | 8 (24.2) | - |
| Serum CA 19-9 (U/mL) | 118.73 (0.1-2,270) | 1,702 (0.1-20,000) | 0.097 |
| Normal | 38 (65.6) | 15 (45.5) | 0.035 |
| > 24 | 14 (25.0) | 15 (45.5) | - |
| Serum CA-125 (U/mL) | 36.4 (4-241) | 60.82 (5-227.8) | 0.117 |
| Normal | 33 (56.9) | 10 (30.3) | 0.08 |
| > 35 | 11 (19.0) | 9 (27.3) | - |
Values are presented as median (range) or number (%). WD-MD, well differentiated adenocarcinoma and moderately differentiated adenocarcinoma; PD-SRC, poorly differentiated adenocarcinoma and signet ring cell carcinoma; AJCC, American Joint Committee on Cancer; CEA, carcinoembryonic antigen; CA, cancer antigen.
a)
Patients were divided into two arms according to treatment modality: arm A, metastasectomy plus chemotherapy; arm B, chemotherapy alone,
b)
p-values from chi-square test except for Krukenberg tumor size, median age at Krukenberg tumor diagnosis, and relapse free survival, which were determined by a two-tailed Student t test.