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Lifelong in vivo tracing of follicle lineages in mouse ovaries. Using a Foxl2 -CreERT2;mT/mG mouse model (A) or Gdf9-Cre;iDTR mouse model (B), the existing follicle pool is selectively labeled or ablated in early life in vivo. At the end of the reproductive lives of the animals, no follicular regeneration is observed.
