Figure 3.

Edelfosine treatment produces embryonic lethality due to cell structural and embryonic morphological defects. Early embryos were mounted under the microscope using a 20 μM edelfosine solution and their development was recorded for up to 17 h. Time (minutes) is indicated at the top of the figure. Seven independent experiments containing 10 embryos are shown in the different rows and the time of death is shown. The observed defects are indicated: loss of normal cell structure (2^nd, 6^th and 7^th-right row embryos) and morphogenesis defects at ventral enclosure (1^st, 7^th-left rows embryos).