Figure 4.

Edelfosine-induced embryonic lethality depends on cholesterol. (A) Percentage of surviving embryos laid by worms treated with edelfosine when maintained on NGM plates without or with different concentrations of cholesterol. Each data point represents the mean values ± SD of at least 3 independent experiments (see Table S1 for details). (B) Percentage of surviving embryos (n = 144–205 per treatment) when worms are treated with or without edelfosine and in the presence or absence of methyl-β-cyclodextrin (MCD). NGM treatment plates are prepared without cholesterol. Each bar in the histogram represents the mean values ± SD of at least 3 independent experiments.