Table 1.
Miltefosine has less affinity to cholesterol than other ATLs
| ATL used | LD50 in media with cholesterola | LD50 in media without cholesterolb | Fold differencec | Expected LD50d |
|---|---|---|---|---|
| Edelfosine | 12.4 μM | 3.8 μM | 3.2 fold | 12.4 μM |
| Perifosine | 17.5 μM | 7.0 μM | 2.5 fold | 22.4 μM |
| Erucylphosphocholine | 30.0 μM | 9.0 μM | 3.3 fold | 28.8 μM |
| Miltefosine | 52.0 μM | 37.0 μM | 1.4 fold | 118.4 μM |
a
plates supplemented with 5 μg cholesterol/ml of NGM.
b
NGM plates without cholesterol.
c
fold difference between LD50 in media with cholesterol and LD50 in media without cholesterol.
d
expected LD50 relative to LD50 fold difference observed for edelfosine.